FIT (Vertebral Fracture Arm)
Fracture Intervention Trial — Vertebral Fracture Arm
Patient / Population Intervention / Exposure Comparison Outcome
In 2,027 postmenopausal women with ≥1 prevalent vertebral fracture, alendronate reduced new vertebral, clinical and hip fractures compared with placebo.
N
2,027
Design
Double-blind RCT, 36 mo
Endpoint
New morphometric vertebral fracture
Relevance
1
ResultVertebral fracture RR 0.53; clinical vertebral RR 0.45; hip fracture RR 0.49 (p=0.047).
Black DM, et al. Lancet. 1996;348(9041):1535-1541. 10.1016/S0140-6736(96)07088-2
Discussion & critique
Established bisphosphonates as first-line antifracture therapy — still the foundation of modern osteoporosis treatment.