FACTT
Comparison of Two Fluid-Management Strategies in ARDS
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,000 patients with ARDS, a conservative fluid strategy did not change 60-day mortality versus a liberal strategy, but increased ventilator-free days.
N
1.000
Design
Multicentre RCT, ARDS Network
Endpunkt
60-day mortality
Relevanz
2
Ergebnis25.5% vs 28.4% (NS); VFDs +2.5; ICU-free days +2.2.
Wiedemann HP, et al. N Engl J Med. 2006;354(24):2564-2575. 10.1056/NEJMoa062200
Diskussion & Kritik
Standard of care: keep ARDS dry once shock is resolved.