EVEREST II
Endovascular Valve Edge-to-Edge Repair Study II
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 279 patients with grade 3+/4+ mitral regurgitation, percutaneous MitraClip repair was less effective at reducing death, mitral surgery, or residual MR at 12 months but safer than mitral valve surgery.
N
279
Design
Multicentre RCT (2:1), non-inferiority for efficacy
Endpunkt
Freedom from death, mitral-valve surgery, and 3+/4+ MR at 12 months
Relevanz
3
ErgebnisPercutaneous repair 55% vs surgery 73% for the efficacy composite (P=0.007; surgery more effective), but MitraClip had far fewer 30-day major adverse events (15% vs 48%, P<0.001).
Feldman T, et al. N Engl J Med. 2011;364(15):1395-1406. 10.1056/NEJMoa1009355
Diskussion & Kritik
Enrolled mostly degenerative MR in good surgical candidates, and residual MR common with the clip. Established MitraClip as safer but less durable, positioning it for high-risk primary MR and later functional MR (COAPT).