EUROTHERM3235
Hypothermia for Intracranial Hypertension after TBI
Patient / Population Intervention / Exposure Comparison Outcome
In 387 patients with TBI and refractory raised intracranial pressure, therapeutic hypothermia 32–35 °C worsened 6-month functional outcome compared with standard care.
N
387
Design
Multicentre RCT; stopped early for harm
Endpoint
Extended Glasgow Outcome Score at 6 months
Relevance
2
ResultFavourable outcome 26% vs 37% (OR 1.53 for worse outcome; p=0.04).
Andrews PJ, et al. N Engl J Med. 2015;373(25):2403-2412. 10.1056/NEJMoa1507581
Discussion & critique
Don't prophylactically cool TBI for raised ICP; routine hypothermia harms.