EPIC-HR
Nirmatrelvir-Ritonavir in High-Risk Outpatients with COVID-19
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 2,246 high-risk unvaccinated adults with COVID-19, nirmatrelvir-ritonavir within 5 days of symptom onset reduced COVID-19-related hospitalisation or death by day 28 compared with placebo.
N
2246
Disegno
Double-blind RCT
Esito
Hospitalisation or death at 28 days
Rilevanza
2
Risultato0.77 % vs 6.31 %; ~89 % relative reduction.
Hammond J, et al. N Engl J Med. 2022;386(15):1397-1408. 10.1056/NEJMoa2118542
Discussione e critica
Cornerstone outpatient antiviral — caveat: efficacy in vaccinated lower-risk patients and drug-drug interactions limit real-world impact.