EOLIA
Extracorporeal Membrane Oxygenation for Severe ARDS
Patient / Population Intervention / Exposure Comparison Outcome
In 249 patients with very severe ARDS, early VV-ECMO did not significantly reduce 60-day mortality versus conventional ventilation with rescue ECMO.
N
249
Design
Multicentre RCT, stopped early
Endpoint
60-day mortality
Relevance
2
Result35% vs 46% (RR 0.76; 95% CI 0.55–1.04; p=0.09); 28% crossover to ECMO. Bayesian re-analysis favoured ECMO.
Combes A, et al. N Engl J Med. 2018;378(21):1965-1975. 10.1056/NEJMoa1800385
Discussion & critique
With Bayesian re-analysis supports VV-ECMO as rescue at experienced centres.