ELITE-Symphony
Efficacy Limiting Toxicity Elimination — Symphony Study
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 1,645 kidney-transplant recipients, low-dose tacrolimus with mycophenolate and steroids gave better graft function than the other immunosuppressive regimens.
N
1645
Disegno
Open-label RCT, four arms
Esito
eGFR at 12 months
Rilevanza
1
RisultatoLow-dose tacrolimus 65.4 mL/min (superior; p<0.001); biopsy-proven rejection 12.3% and graft survival 94.2%.
Ekberg H, et al. N Engl J Med. 2007;357(25):2562-2575. 10.1056/NEJMoa067411
Discussione e critica
Established low-dose tacrolimus plus mycophenolate and steroids as the de-novo standard.