DELIVER
Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved-EF Heart Failure
Paciente / Población Intervención / Exposición Comparación Desenlace
In 6,263 patients with heart failure and an ejection fraction > 40 %, dapagliflozin reduced worsening heart failure or cardiovascular death compared with placebo.
N
6263
Diseño
Double-blind RCT
Desenlace
Worsening HF or CV death
Relevancia
2
Resultado16.4 % vs 19.5 % (HR 0.82); benefit consistent across the EF spectrum.
Solomon SD, et al. N Engl J Med. 2022;387(12):1089-1098. 10.1056/NEJMoa2206286
Discusión y crítica
With EMPEROR-Preserved, made SGLT2 inhibitors the first broadly effective HFpEF therapy. Driven by HF events; mortality not significantly reduced.