DECRA
Decompressive Craniectomy in Diffuse Traumatic Brain Injury
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 155 patients with severe diffuse TBI and refractory raised ICP, early bifrontal craniectomy worsened 6-month functional outcome versus standard care.
N
155
Design
Multicentre RCT, ANZ
Endpunkt
Extended Glasgow Outcome Score at 6 months
Relevanz
2
ErgebnisOR 1.84 for worse functional outcome (p=0.03); similar mortality.
Cooper DJ, et al. N Engl J Med. 2011;364(16):1493-1502. 10.1056/NEJMoa1102077
Diskussion & Kritik
Tempered enthusiasm for early craniectomy; refractory ICP alone is not enough.