de Gans 2002

Dexamethasone in Adults with Bacterial Meningitis

Paciente / Población Intervención / Exposición Comparación Desenlace

In 301 adults with suspected community-acquired bacterial meningitis, dexamethasone 10 mg every 6 h for 4 days started before or with the first antibiotic dose reduced unfavourable outcome and mortality compared with placebo.

301

Diseño

Double-blind RCT

Desenlace

Unfavourable Glasgow Outcome Score at 8 weeks

Relevancia

ResultadoUnfavourable outcome 15 % vs 25 %; mortality 7 % vs 15 %; benefit driven by S. pneumoniae subgroup.

de Gans J, van de Beek D. N Engl J Med. 2002;347(20):1549-1556. 10.1056/NEJMoa021334

Discusión y crítica

Adjunctive dexamethasone with/before the first antibiotic dose is standard in high-income settings — continued only if pneumococcal disease is confirmed.