CRHCP
China Rural Hypertension Control Project (CRHCP) — Effectiveness of a Standardized Protocol-based Treatment Program on Hypertension Control in Rural China
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 33,995 rural Chinese adults with hypertension, village-doctor-led intensive blood-pressure control was compared with usual care on all-cause dementia.
N
33 995
Schéma
Open-label, cluster-randomised, blinded-endpoint trial; 326 villages in rural China randomised 1:1 (163 villages to intervention, 163 to usual care); village doctor-led multifaceted intervention (protocol-based antihypertensive initiation and titration to a target <130/80 mmHg, home BP monitoring, health coaching, specialist supervision, performance-based incentives) versus usual care; phased primary outcomes at 18 months (BP control), 36 months (composite CVD) and 48 months (all-cause dementia), with an extension study to year 7; outcome assessment committee blinded.
Critère
All-cause dementia (Phase 3 primary outcome, assessed at 48 months after baseline); the Hot Line presentation covers longer-term follow-up of BP control and dementia risk