CORTICUS
Corticosteroid Therapy of Septic Shock
Doente / População Intervenção / Exposição Comparação Desfecho
In 499 patients with septic shock, hydrocortisone 200 mg/day did not reduce 28-day mortality versus placebo.
N
499
Desenho
Double-blind RCT
Desfecho
28-day mortality in ACTH non-responders
Relevância
3
Resultado39.2% vs 36.1% (p=0.69); overall 34.3% vs 31.5%.
Sprung CL, et al. N Engl J Med. 2008;358(2):111-124. 10.1056/NEJMoa071366
Discussão e crítica
Discredited the ACTH stimulation test as a steroid-selection tool; tempered enthusiasm until ADRENAL/APROCCHSS reset the question.