CorCal
CorCal Outcomes — Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events
Paciente / Población Intervención / Exposición Comparación Desenlace
In 5,772 statin-naïve adults in primary prevention, coronary calcium score-guided statin therapy was compared with risk score-guided statin therapy on major adverse cardiovascular events.
N
5772
Diseño
Single health-system (Intermountain Health, Utah), open-label, 1:1 randomised non-inferiority trial; patients identified by EHR query and randomly invited; primary analysis by modified per-protocol approach (all who completed baseline testing and received a statin recommendation, n = 5,329); event follow-up up to 5 years via EHR; projected completion second quarter 2026
Desenlace
MACE — composite of all-cause mortality, myocardial infarction, stroke and revascularisation (coronary, carotid and peripheral)