CoBalT

CBT as Adjunct in Treatment-Resistant Depression

Patient / Population Intervention / Exposition Comparaison Critère de jugement

In 469 primary-care patients with antidepressant-resistant depression, 12–18 sessions of CBT added to usual care improved 6-month response and sustained benefit at 46 months compared with usual care alone.

469

Schéma

Multicentre RCT, UK

Critère

≥50% BDI reduction at 6 months

Pertinence

RésultatResponse 46% (CBT) vs 22% (UC); OR 3.26. Benefit persisted at 46 months (Lancet Psychiatry 2016).

Wiles N, et al. Lancet. 2013;381(9864):375-384. 10.1016/S0140-6736(12)61552-9

Discussion et critique

Established CBT as a routine second-line strategy in primary care before further drug switches.