CoBalT
CBT as Adjunct in Treatment-Resistant Depression
Patient / Population Intervention / Exposure Comparison Outcome
In 469 primary-care patients with antidepressant-resistant depression, 12–18 sessions of CBT added to usual care improved 6-month response and sustained benefit at 46 months compared with usual care alone.
N
469
Design
Multicentre RCT, UK
Endpoint
≥50% BDI reduction at 6 months
Relevance
2
ResultResponse 46% (CBT) vs 22% (UC); OR 3.26. Benefit persisted at 46 months (Lancet Psychiatry 2016).
Wiles N, et al. Lancet. 2013;381(9864):375-384. 10.1016/S0140-6736(12)61552-9
Discussion & critique
Established CBT as a routine second-line strategy in primary care before further drug switches.