CLASSIC
Conservative versus Liberal Approach to Fluid Therapy in Septic Shock
Paciente / Población Intervención / Exposición Comparación Desenlace
In 1,554 ICU patients with septic shock after initial resuscitation, restrictive intravenous fluids did not change 90-day mortality compared with standard fluids.
N
1554
Diseño
Multicentre RCT, European
Desenlace
90-day all-cause mortality
Relevancia
2
Resultado42.3% vs 42.1% (adjusted RR 0.99; 95% CI 0.89–1.10). Median IV fluid 1,798 vs 3,811 mL.
Meyhoff TS, et al. N Engl J Med. 2022;386(26):2459-2470. 10.1056/NEJMoa2202707
Discusión y crítica
Restricting IV fluid after initial resuscitation in established septic shock is safe.