CLASSIC
Conservative versus Liberal Approach to Fluid Therapy in Septic Shock
Patient / Population Intervention / Exposure Comparison Outcome
In 1,554 ICU patients with septic shock after initial resuscitation, restrictive intravenous fluids did not change 90-day mortality compared with standard fluids.
N
1,554
Design
Multicentre RCT, European
Endpoint
90-day all-cause mortality
Relevance
2
Result42.3% vs 42.1% (adjusted RR 0.99; 95% CI 0.89–1.10). Median IV fluid 1,798 vs 3,811 mL.
Meyhoff TS, et al. N Engl J Med. 2022;386(26):2459-2470. 10.1056/NEJMoa2202707
Discussion & critique
Restricting IV fluid after initial resuscitation in established septic shock is safe.