CAPE COD
Hydrocortisone in Severe Community-Acquired Pneumonia
Doente / População Intervenção / Exposição Comparação Desfecho
In 800 ICU patients with severe community-acquired pneumonia, continuous hydrocortisone 200 mg/day, tapered after day 4 reduced 28-day mortality compared with placebo.
N
800
Desenho
Multicentre RCT, France
Desfecho
28-day all-cause mortality
Relevância
2
Resultado6.2% vs 11.9% (absolute difference -5.6%; p=0.006). Lower intubation (HR 0.77) and vasopressor need.
Dequin PF, et al. N Engl J Med. 2023;388(21):1931-1941. 10.1056/NEJMoa2215145
Discussão e crítica
Established hydrocortisone in severe CAP requiring ICU care; reshapes ATS/IDSA/ERS guidance.