Brochard NIV
Noninvasive Ventilation for Acute Exacerbations of COPD
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 85 patients with acute hypercapnic respiratory failure from COPD, face-mask non-invasive ventilation reduced intubation and in-hospital mortality compared with standard therapy.
N
85
Disegno
RCT, France
Esito
Intubation and mortality
Rilevanza
1
RisultatoIntubation 26% vs 74% (p<0.001); hospital mortality 9% vs 29% (p=0.02); LOS 23 vs 35 days.
Brochard L, et al. N Engl J Med. 1995;333(13):817-822. 10.1056/NEJM199509283331301
Discussione e critica
Foundational trial for NIV in acute hypercapnic COPD exacerbation; cornerstone of every modern guideline.