BLOCK-COPD
Beta-Blockers for the Prevention of Acute Exacerbations of COPD
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 532 patients with moderate-to-severe COPD without cardiac indication for β-blockade, metoprolol succinate did not reduce time to first exacerbation and increased severe exacerbations compared with placebo.
N
532
Disegno
Multicentre RCT, stopped early
Esito
Time to first COPD exacerbation
Rilevanza
2
RisultatoHR 1.05 (p=0.66); severe exacerbations HR 1.91 (95% CI 1.29–2.83).
Dransfield MT, et al. N Engl J Med. 2019;381(24):2304-2314. 10.1056/NEJMoa1908142
Discussione e critica
Prophylactic β-blockade is harmful in COPD without a cardiac indication; informs cardiology co-management.