Bernard 2002
Therapeutic Hypothermia after VF Arrest (Bernard)
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 77 comatose survivors of out-of-hospital VF arrest, hypothermia to 33 °C improved good neurologic outcome compared with normothermia.
N
77
Disegno
Quasi-randomised single-country RCT
Esito
Good neurologic outcome at discharge
Rilevanza
3
Risultato49% vs 26% (p=0.046).
Bernard SA, et al. N Engl J Med. 2002;346(8):557-563. 10.1056/NEJMoa003289
Discussione e critica
Underpowered and quasi-randomised; effect later not reproduced in TTM/TTM2.