Barlow Panic
CBT vs Imipramine for Panic Disorder
Doente / População Intervenção / Exposição Comparação Desfecho
In 312 outpatients with panic disorder, CBT, imipramine or their combination improved acute response and long-term durability compared with placebo or CBT + placebo.
N
312
Desenho
5-arm RCT, USA
Desfecho
Panic Disorder Severity Scale response
Relevância
1
ResultadoAll active arms > placebo acutely; in follow-up CBT more durable than imipramine.
Barlow DH, et al. JAMA. 2000;283(19):2529-2536. 10.1001/jama.283.19.2529
Discussão e crítica
Pivotal head-to-head trial; CBT preserves gains after taper while imipramine relapses.