Barlow Panic
CBT vs Imipramine for Panic Disorder
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 312 outpatients with panic disorder, CBT, imipramine or their combination improved acute response and long-term durability compared with placebo or CBT + placebo.
N
312
Schéma
5-arm RCT, USA
Critère
Panic Disorder Severity Scale response
Pertinence
1
RésultatAll active arms > placebo acutely; in follow-up CBT more durable than imipramine.
Barlow DH, et al. JAMA. 2000;283(19):2529-2536. 10.1001/jama.283.19.2529
Discussion et critique
Pivotal head-to-head trial; CBT preserves gains after taper while imipramine relapses.