ATACH-2
Antihypertensive Treatment of Acute Cerebral Haemorrhage 2
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 1,000 patients with acute ICH, aggressive SBP 110–139 mm Hg did not change 90-day death or disability versus standard 140–179 mm Hg, with more renal adverse events.
N
1000
Disegno
Multicentre RCT
Esito
90-day death or disability (mRS 4–6)
Rilevanza
2
Risultato38.7% vs 37.7% (NS); more renal AEs in aggressive.
Qureshi AI, et al. N Engl J Med. 2016;375(11):1033-1043. 10.1056/NEJMoa1603460
Discussione e critica
Aggressive lowering doesn't help and may harm; target ~140 mm Hg.