ATACH-2
Antihypertensive Treatment of Acute Cerebral Haemorrhage 2
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 1,000 patients with acute ICH, aggressive SBP 110–139 mm Hg did not change 90-day death or disability versus standard 140–179 mm Hg, with more renal adverse events.
N
1 000
Schéma
Multicentre RCT
Critère
90-day death or disability (mRS 4–6)
Pertinence
2
Résultat38.7% vs 37.7% (NS); more renal AEs in aggressive.
Qureshi AI, et al. N Engl J Med. 2016;375(11):1033-1043. 10.1056/NEJMoa1603460
Discussion et critique
Aggressive lowering doesn't help and may harm; target ~140 mm Hg.