ARMA
ARDS Network: Lower Tidal Volumes for Acute Lung Injury
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 861 patients with ARDS, 6 mL/kg tidal-volume ventilation reduced in-hospital mortality compared with 12 mL/kg.
N
861
Design
Multicentre RCT
Endpunkt
In-hospital mortality and ventilator-free days at 28 days
Relevanz
1
ErgebnisMortality 31.0% vs 39.8% (Δ −8.8%; p=0.007); VFDs 12 vs 10.
ARDS Network. N Engl J Med. 2000;342(18):1301-1308. 10.1056/NEJM200005043421801
Diskussion & Kritik
Founded modern lung-protective ventilation; the strongest mortality signal in ARDS.