ARISE

Australasian Resuscitation in Sepsis Evaluation

Patient / Population Intervention / Exposure Comparison Outcome

In 1,600 patients with early septic shock, EGDT did not change 90-day all-cause mortality versus usual care.

1,600

Design

Multicentre RCT, Australia/NZ

Endpoint

90-day all-cause mortality

Relevance

Result18.6% vs 18.8% (Δ −0.3%; p=0.90).

ARISE Investigators. N Engl J Med. 2014;371(16):1496-1506. 10.1056/NEJMoa1404380

Discussion & critique

Companion to ProCESS/ProMISe; together they ended bundled EGDT.