APROCCHSS

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

Patient / Population Intervention / Exposition Comparaison Critère de jugement

In 1,241 patients with septic shock on vasopressors ≥6 hours, hydrocortisone + fludrocortisone reduced 90-day mortality compared with placebo.

1 241

Schéma

Double-blind RCT, France

Critère

90-day all-cause mortality

Pertinence

Résultat43.0% vs 49.1% (RR 0.88; 95% CI 0.78–0.99; p=0.03).

Annane D, et al. N Engl J Med. 2018;378(9):809-818. 10.1056/NEJMoa1705716

Discussion et critique

Sicker enrolment than ADRENAL; together they justify hydrocortisone ± fludrocortisone in vasopressor-dependent septic shock.