APROCCHSS
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,241 patients with septic shock on vasopressors ≥6 hours, hydrocortisone + fludrocortisone reduced 90-day mortality compared with placebo.
N
1.241
Design
Double-blind RCT, France
Endpunkt
90-day all-cause mortality
Relevanz
2
Ergebnis43.0% vs 49.1% (RR 0.88; 95% CI 0.78–0.99; p=0.03).
Annane D, et al. N Engl J Med. 2018;378(9):809-818. 10.1056/NEJMoa1705716
Diskussion & Kritik
Sicker enrolment than ADRENAL; together they justify hydrocortisone ± fludrocortisone in vasopressor-dependent septic shock.