AMPLE
Australasian Malignant Pleural Effusion Trial
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 146 patients with symptomatic malignant pleural effusion, indwelling pleural catheter reduced hospital days during the first year compared with talc pleurodesis.
N
146
Design
Multicentre open-label RCT, Australia/NZ/Singapore/Hong Kong (9 centres)
Endpunkt
Hospital days within 1 year
Relevanz
3
ErgebnisIPC vs talc median 10 vs 12 hospital days (p=0.03); effusion-related days 1 vs 4 (p<.001); re-intervention 4.1% vs 22.5% (p=.001); QoL similar.
Thomas R, et al. JAMA. 2017;318(19):1903-1912. 10.1001/jama.2017.17426
Diskussion & Kritik
IPC is non-inferior for symptom control and reduces hospitalisation versus talc pleurodesis.