ALVEOLI
Higher versus Lower Positive End-Expiratory Pressures in ARDS
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 549 patients with ARDS, a higher PEEP strategy did not reduce in-hospital mortality compared with a lower PEEP strategy.
N
549
Disegno
Multicentre RCT
Esito
In-hospital mortality before discharge with unassisted breathing
Rilevanza
3
Risultato24.9% vs 27.5% (NS).
Brower RG, et al. N Engl J Med. 2004;351(4):327-336. 10.1056/NEJMoa032193
Discussione e critica
Routine high PEEP doesn't help unselected ARDS; later analyses suggest benefit in moderate–severe disease.