ALVEOLI
Higher versus Lower Positive End-Expiratory Pressures in ARDS
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 549 patients with ARDS, a higher PEEP strategy did not reduce in-hospital mortality compared with a lower PEEP strategy.
N
549
Design
Multicentre RCT
Endpunkt
In-hospital mortality before discharge with unassisted breathing
Relevanz
3
Ergebnis24.9% vs 27.5% (NS).
Brower RG, et al. N Engl J Med. 2004;351(4):327-336. 10.1056/NEJMoa032193
Diskussion & Kritik
Routine high PEEP doesn't help unselected ARDS; later analyses suggest benefit in moderate–severe disease.