A-CLOSE
A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients (A-CLOSE)
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 3,200 high-risk patients after 12 months of DAPT following PCI, clopidogrel monotherapy was compared with extended dual antiplatelet therapy on net adverse clinical events at 24 months.
N
3.200
Design
Investigator-initiated, multicentre, open-label randomised controlled trial in South Korea (Yonsei University); 1:1 randomisation at 12 months (window −1 to +5 months) after drug-eluting stent implantation to clopidogrel monotherapy or continued aspirin plus clopidogrel; 24 months of assigned treatment and follow-up
Endpunkt
Net adverse clinical events at 24 months — composite of all-cause death, myocardial infarction, stent thrombosis, stroke or BARC type 2, 3 or 5 bleeding