USPSTF 2021 Lung Cancer Screening

Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement

Annual low-dose CT for adults aged 50 to 80 who have smoked 20 pack-years and who either still smoke or stopped within the past 15 years, graded B. The 2013 statement it replaces began at 55 and required 30 pack-years, so the change lowers both thresholds and roughly doubles the number of people eligible, with the largest gain among women and Black adults, in whom lung cancer develops after less smoking. Screening stops once 15 years have passed since quitting, or once a health problem limits the willingness or ability to have surgery. The statement rests on two trials, one American and one European, which the register carries below. Both found fewer lung cancer deaths; neither settles what to do with the nodules screening finds, which is the question the ERS is writing its own guideline on.

Esta norma cita 2 dos 35 ensaios marcantes do nosso registo de Pneumologia.

Fonte
US Preventive Services Task Force. JAMA. 2021;325(10):962-970.

The two screening trials2

  • 2020NELSONPneumo · Rastreio CP · TC de baixa doseEm 15.789 homens de alto risco (e uma pequena subpopulação feminina), a TCBD volumétrica na linha de base, 1, 3 e 5,5 anos reduziu a mortalidade por cancro do pulmão aos 10 anos em comparação com sem rastreio.
  • 2011NLSTPneumo · Rastreio CP · TC de baixa doseEm 53.454 fumadores e ex-fumadores intensivos de alto risco, três TC torácicas anuais de baixa dose reduziram a mortalidade por cancro do pulmão em comparação com radiografia torácica anual.