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ESC 2025 Pregnancy

2025 ESC Guidelines for the management of cardiovascular disease and pregnancy

The 2025 ESC guideline treats pregnancy as a cardiovascular stress test that many women fail for the first time, and it builds pre-conception counselling, the modified WHO risk classification and the Pregnancy Heart Team into routine care. Its firmest randomised evidence is in hypertensive disorders — where CHAP finally settled the question of whether to treat mild chronic hypertension — and in pre-eclampsia prophylaxis.

This guideline cites 3 of the 199 landmark trials in our Cardiology register.

Source
De Backer J, Roos-Hesselink JW, et al. Eur Heart J. 2025;46(43):4462–4568. · European Heart Journal
Read the full guideline ↗

Hypertension in pregnancy2

  • 2022CHAPCardiology · HTN · Hypertension in pregnancyChronic Hypertension and Pregnancy trial
  • 2015CHIPSCardiology · HTN · Hypertension in pregnancyControl of Hypertension In Pregnancy Study

Pre-eclampsia — prevention & treatment1

  • 2017ASPRECardiology · HTN · Pre-eclampsia preventionAspirin for Evidence-Based Preeclampsia Prevention trial