ESC 2024 PAAD

2024 ESC Guidelines for the management of peripheral arterial and aortic diseases

The 2024 ESC guideline merges peripheral arterial and aortic disease into one document, treating the arterial tree as a single organ. It covers antithrombotic therapy in peripheral artery disease, revascularisation in chronic limb-threatening ischaemia, aneurysm thresholds and surveillance, type B dissection and carotid disease. The register's landmark trials are grouped by vascular bed below.

This guideline cites 13 of the 199 landmark trials in our Cardiology register.

Source
Mazzolai L, Teixido-Tura G, et al. Eur Heart J. 2024;45(36):3538–3700. · European Heart Journal

Peripheral artery disease — antithrombotic therapy3

  • 2020VOYAGER PADCardiology · Vascular · Antithrombotic therapyVascular Outcomes Study of ASA Along with Rivaroxaban in Endovascular or Surgical Limb Revascularization for PAD
  • 2017EUCLIDCardiology · Vascular · Antithrombotic therapyExamining Use of Ticagrelor in Symptomatic Peripheral Artery Disease
  • 2017COMPASSCardiology · Thrombosis · Chronic atherosclerosisCardiovascular Outcomes for People Using Anticoagulation Strategies

Chronic limb-threatening ischaemia — revascularisation2

  • 2023BASIL-2Cardiology · Vascular · RevascularisationBypass versus Angioplasty for Severe Ischaemia of the Leg – 2
  • 2022BEST-CLICardiology · Vascular · RevascularisationBest Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia

Abdominal aortic aneurysm3

  • 2016EVAR-1Cardiology · Vascular · Aortic aneurysmUK Endovascular Aneurysm Repair Trial 1 — 15-year follow-up
  • 2014IMPROVECardiology · Vascular · Aortic aneurysmImmediate Management of the Patient with Rupture: Open Versus Endovascular Repair
  • 1998UK Small Aneurysm TrialCardiology · Vascular · Aortic aneurysmUK Small Aneurysm Trial — early elective surgery versus ultrasonographic surveillance

Type B aortic dissection1

  • 2013INSTEAD-XLCardiology · Vascular · Aortic dissectionInvestigation of Stent Grafts in Aortic Dissection — eXtended Long-term follow-up

Carotid artery disease2

  • 2021ACST-2Cardiology · Vascular · Carotid diseaseSecond Asymptomatic Carotid Surgery Trial
  • 2010CRESTCardiology · Vascular · Carotid diseaseCarotid Revascularization Endarterectomy versus Stenting Trial

Risk-factor modification2

  • 2017FOURIERCardiology · Lipids · PCSK9iFurther Cardiovascular Outcomes Research with PCSK9 Inhibition
  • 2000HOPECardiology · Coronary · ACE inhibitorHeart Outcomes Prevention Evaluation