SGEM Xtra: Carl Heneghan – Legend of Evidence-Based Medicine

Ensaios extraídos do podcast de Dr. Ken Milne

• 1994ATCAnticoagulation & AntithromboticsIn about 100,000 patients at high or low risk of occlusive vascular disease, prolonged antiplatelet therapy reduced serious vascular events compared with control.
• 2014Neuraminidase inhibitors for preventing and treating influenza in adults and childrenInfection & AntimicrobialsIn 24,251 people with influenza-like illness, neuraminidase inhibitors shortened symptoms by under a day versus placebo, without reducing hospital admissions
• 1989CASTElectrophysiology & AFIn 1727 post-infarction patients with suppressed ventricular ectopy, encainide or flecainide raised arrhythmic death and total mortality versus placebo.
• 2013Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood AutismPsychiatry & BehaviouralIn 655,615 Danish children, prenatal valproate exposure raised the risk of autism spectrum disorder compared with no prenatal exposure.
• 2012Failure rates of stemmed metal-on-metal hip replacementsOtherIn 402,051 primary hip replacements, stemmed metal-on-metal bearings raised 5-year revision compared with metal-on-polyethylene or ceramic bearings.
• 1997Does This Patient Have Community-Acquired Pneumonia?Imaging & DiagnosticsInadults with acute respiratory symptoms and suspected pneumonia,history and physical examinationwere compared withchest radiographyfordiagnosing community-acquired pneumonia.
• 2024Cass ReviewPsychiatry & BehaviouralIn 113,269 children and adolescents with gender dysphoria, evidence on puberty suppression and hormones was mostly low quality, with no controls