SGEM Xtra: Tell Me Lies, Sweet Little Lies – FDA Approved & Ineffective

Ensaios extraídos do podcast de Dr. Ken Milne

• 2025FDA Approved — And IneffectiveOtherOf 429 FDA drug approvals from 2013 to 2022, review against the agency's four evidence standards found 73% failed at least one, versus 28% meeting all
• 2015Pentosan Polysulfate Sodium for Interstitial Cystitis/Bladder Pain Syndrome (NCT00086684)OtherIn368 adults with interstitial cystitis/bladder pain syndrome,pentosan polysulfate sodiumdid not improvesymptom scores at 24 weekscompared withplacebo.
• 2018DUOOncology & HaematologyIn 319 patients with relapsed or refractory CLL/SLL, duvelisib prolonged progression-free survival compared with ofatumumab, without a gain in overall survival.
• 1989CASTElectrophysiology & AFIn 1727 patients with asymptomatic ventricular ectopy after myocardial infarction, encainide or flecainide raised mortality compared with placebo.
• 2011Treatment of Acute Otitis Media in Children under 2 Years of AgeInfection & AntimicrobialsIn 291 children 6-23 months with acute otitis media, amoxicillin-clavulanate hastened symptom resolution and reduced persistent otoscopic signs versus placebo.