TrialsgrambetaRCTs are beautiful

SGEM#465: Not A Second Time – Single Center RCTs Fail To Replicate In Multi-Center RCTs

6 trials

Trials extracted from the podcast by Dr. Ken Milne

  • 2023Positive single-center RCTs and subsequent multicenter RCTs in critically ill patientsICU & Critical CareIn 19 positive single-center ICU trials, subsequent multicenter trials replicated the mortality reduction of the single-center result in only 1 of 16 cases.
  • 2018BEAMEmergency & ResuscitationIn 757 adults undergoing emergency intubation, a bougie increased first-attempt intubation success compared with an endotracheal tube plus stylet.
  • 2021BOUGIEICU & Critical CareIn 1102 critically ill adults undergoing emergency intubation, a bougie did not improve first-attempt success compared with an endotracheal tube with stylet.
  • 2001EGDT (Rivers trial)ICU & Critical CareIn 263 patients with severe sepsis or septic shock, early goal-directed therapy lowered in-hospital mortality compared with standard therapy.
  • 2024PREOXIICU & Critical CareIn 1301 critically ill adults undergoing tracheal intubation, preoxygenation with noninvasive ventilation lowered hypoxemia compared with an oxygen mask.
  • 2001Leuven SurgicalICU & Critical CareIn 1548 mechanically ventilated surgical ICU patients, intensive insulin therapy lowered ICU mortality compared with conventional glucose control.