SGEM#395: Too Much Blood from My Nose – Will TXA Help?

Studien extrahiert aus dem Podcast von Dr. Ken Milne

• 2022Intranasal Topical Application of Tranexamic Acid in Atraumatic Anterior EpistaxisEmergency & ResuscitationIn 240 adults with atraumatic anterior epistaxis, topical tranexamic acid lowered the need for anterior nasal packing versus phenylephrine-lidocaine alone.
• 2013A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topicallyEmergency & ResuscitationIn 216 emergency department patients with anterior epistaxis, topical tranexamic acid stopped bleeding within 10 minutes more often than anterior nasal packing.
• 2018Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet DrugsEmergency & ResuscitationIn 124 adults with anterior epistaxis taking antiplatelet drugs, topical tranexamic acid achieved bleeding cessation at 10 minutes more often than anterior nasal packing.
• 2021NoPACEmergency & ResuscitationIn496 adults with spontaneous epistaxis persisting after first aid,topical tranexamic aciddid not reduce theneed for anterior nasal packingversusplacebo
• 2010CRASH-2Emergency & ResuscitationIn 20,211 adult trauma patients with or at risk of significant bleeding, tranexamic acid reduced all-cause mortality within 4 weeks compared with placebo.
• 2019CRASH-3Emergency & ResuscitationIn 12,737 adults with acute traumatic brain injury, tranexamic acid did not significantly reduce head injury-related death compared with placebo.
• 2017WOMANOtherIn 20 060 women with post-partum haemorrhage, tranexamic acid did not reduce death from all causes or hysterectomy compared with placebo.
• 2020HALT-ITOtherIn12,009 adults with acute gastrointestinal bleeding at risk of death,tranexamic aciddid not reducedeath due to bleeding at 5 dayscompared withplacebo.
• 2018TICH-2OtherIn 2325 adults with spontaneous intracerebral haemorrhage within 8 h of onset, tranexamic acid did not improve day-90 functional status compared with placebo.
• 2021ULTRAOtherIn955 patients with spontaneous subarachnoid haemorrhage,ultra-early tranexamic aciddid not improvegood clinical outcome at 6 monthscompared withcare as usual.