SGEM#377: You Don’t Have to “AcT” that Way – TNK for Acute Ischemic Stroke?

Studi estratti dal podcast di Dr. Ken Milne

• 2022AcTAnticoagulation & AntithromboticsIn 1600 patients with acute ischaemic stroke within 4.5 h of onset, tenecteplase was non-inferior to alteplase for freedom from disability at 90–120 days.
• 1995NINDS rt-PA Stroke StudyAnticoagulation & AntithromboticsIn 624 patients with acute ischaemic stroke treated within 3 hours of onset, intravenous alteplase increased freedom from disability at 3 months versus placebo.
• 2008ECASS IIIAnticoagulation & AntithromboticsIn 821 patients with acute ischaemic stroke 3-4.5 hours after symptom onset, alteplase improved freedom from disability at 90 days compared with placebo.