SGEM Xtra: Are tPA Stroke Trials Really Fragile?

Ensayos extraídos del pódcast de Dr. Ken Milne

• 2022Fragility Index Meta-Analysis of RCTs of <3 Hour Intravenous AlteplaseAnticoagulation & AntithromboticsIn patients with acute ischemic stroke within 3 hours of onset, intravenous alteplase increased freedom from disability compared with control.
• 1995NINDS Part 2Anticoagulation & AntithromboticsIn 333 patients with acute ischemic stroke within 3 hours of onset, intravenous t-PA improved favourable outcome at three months compared with placebo.
• 2012IST-3Anticoagulation & AntithromboticsIn 3035 patients with acute ischaemic stroke within 6 h of onset, intravenous rt-PA did not increase survival free of disability at 6 months versus control.