SGEM#371: All My LOVIT, Vitamin C Won’t Work for You

Studien extrahiert aus dem Podcast von Dr. Ken Milne

• 2022LOVITICU & Critical CareIn 872 ICU adults with sepsis receiving vasopressors, intravenous vitamin C increased death or persistent organ dysfunction at day 28 compared with placebo.
• 2019CITRIS-ALIICU & Critical CareIn 167 patients with sepsis and ARDS, intravenous vitamin C did not improve organ dysfunction or inflammation biomarkers compared with placebo.
• 2017Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic ShockICU & Critical CareIn 94 patients with severe sepsis or septic shock, vitamin C, hydrocortisone and thiamine was associated with lower hospital mortality than historical standard care.
• 2017Evaluation of Evidence of Statistical Support and Corroboration of Subgroup Claims in Randomized Clinical TrialsOtherAmong 64 randomized trials with abstract subgroup claims, subsequent RCTs and meta-analyses reproduced none of the subgroup differences claimed by the index trials.