SGEM#368: Just A Normal Saline Day in the ICU – The PLUS Study

Studi estratti dal podcast di Dr. Ken Milne

• 2022PLUSICU & Critical CareIn 5037 critically ill adults in the ICU, balanced multielectrolyte solution did not reduce 90-day all-cause mortality compared with 0.9% saline.
• 2021BaSICSICU & Critical CareIn 11 052 critically ill adults in Brazilian ICUs requiring fluid expansion, a balanced solution did not improve 90-day survival compared with 0.9% saline.
• 2018SMARTICU & Critical CareIn15,802 critically ill adults in the ICU,balanced crystalloidsmodestly reducedmajor adverse kidney events within 30 dayscompared withsaline.
• 2018SALT-EDEmergency & ResuscitationIn 13,347 non-critically ill adults given IV fluids in the emergency department, balanced crystalloids lowered major adverse kidney events at 30 days versus saline.
• 2022Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-AnalysisICU & Critical CareIn35,884 critically ill adults across 13 randomised trials,balanced crystalloidsdid not significantly reduce90-day mortalitycompared withsaline.