SGEM#350: How Did I Get Epi Alone? Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrests

Studien extrahiert aus dem Podcast von Dr. Ken Milne

• 2021VAM-IHCAEmergency & ResuscitationIn 501 adults with in-hospital cardiac arrest, vasopressin plus methylprednisolone increased return of spontaneous circulation compared with placebo.
• 2013VSEEmergency & ResuscitationIn 268 adults with vasopressor-requiring in-hospital cardiac arrest, vasopressin, steroids and epinephrine raised neurologically intact survival to discharge versus epinephrine alone.
• 2018PARAMEDIC2Emergency & ResuscitationIn 8014 adults with out-of-hospital cardiac arrest, epinephrine improved 30-day survival versus placebo, but not survival with favourable neurologic outcome.
• 2020Steroid use after cardiac arrest is associated with favourable outcomesEmergency & ResuscitationIn 9414 adults with cardiac arrest, steroids increased ROSC and survival to discharge compared with no steroids.
• 2021Use of Corticosteroids in Cardiac Arrest - A Systematic Review and Meta-AnalysisEmergency & ResuscitationIn 6,199 cardiac arrest patients, corticosteroids improved neurologic outcome and survival to discharge versus no steroids, only with vasopressin-epinephrine.