SGEM#345: Checking In, Checking Out for Non-Operative Treatment of Appendicitis

Trials extracted from the podcast by Dr. Ken Milne

• 2021APPAC IIInfection & AntimicrobialsIn599 adults with uncomplicated appendicitis,oral moxifloxacinfailed to prove non-inferior for1-year treatment successversusIV-then-oral antibiotics.
• 2015APPACInfection & AntimicrobialsIn530 adults with CT-confirmed uncomplicated acute appendicitis,antibiotic therapywas not non-inferior toappendectomyfortreatment success at one year
• 2019Nonoperative Management of Uncomplicated Appendicitis Among Privately Insured PatientsInfection & AntimicrobialsIn 58,329 patients admitted with uncomplicated appendicitis, nonoperative management raised abscess and readmission rates compared with appendectomy.
• 2008Traditional and Laparoscopic Appendectomy in Adults: Outcomes in English NHS HospitalsOtherIn259,735 adults undergoing emergency appendectomy in English NHS hospitals,laparoscopic appendectomywas followed by lower30-day and 1-year mortalitythanopen appendectomy