SGEM#333: Do you gotta be starting something – like tPA before EVT?

Ensaios extraídos do podcast de Dr. Ken Milne

• 2021SKIPAnticoagulation & AntithromboticsIn 204 patients with large vessel occlusion stroke, thrombectomy alone was not non-inferior for 90-day mRS 0-2 versus bridging intravenous thrombolysis.
• 2021DEVTAnticoagulation & AntithromboticsIn 234 patients with anterior circulation occlusion stroke, thrombectomy alone matched 90-day functional independence versus alteplase plus thrombectomy.
• 2015MR CLEANOtherIn 500 patients with acute proximal anterior-circulation stroke, intraarterial treatment within 6 hours improved 90-day functional outcome versus usual care alone.
• 2015SWIFT PRIMEOtherIn 196 patients with proximal anterior circulation stroke, stent-retriever thrombectomy plus IV t-PA reduced 90-day disability compared with IV t-PA alone.
• 2015EXTEND-IAOtherIn 70 patients with anterior-circulation ischaemic stroke, added stent-retriever thrombectomy improved reperfusion and 90-day independence compared with alteplase alone.
• 2015REVASCATOtherIn 206 patients with anterior circulation stroke within 8 hours, stent-retriever thrombectomy reduced 90-day disability versus medical therapy alone.
• 2015ESCAPEOtherIn 316 patients with proximal anterior-circulation ischemic stroke, thrombectomy improved 90-day functional outcome compared with standard care alone.
• 2018DAWNOtherIn 206 patients with large-vessel stroke 6-24 h from last known well and clinical-infarct mismatch, thrombectomy reduced 90-day disability versus standard care.
• 2018DEFUSE 3OtherIn 182 patients with large-vessel stroke 6–16 hours after last known well, thrombectomy improved 90-day functional outcome compared with medical therapy alone.
• 2015Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysisOtherIn2423 patients with acute ischaemic stroke across 8 randomised trials,endovascular thrombectomyimproved90-day functional independenceversusstandard medical care
• 2017Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke PatientsAnticoagulation & AntithromboticsIn 2943 thrombectomy-treated patients with large-vessel stroke, intravenous thrombolysis improved 90-day functional independence versus thrombectomy alone.
• 2020DIRECT-MTAnticoagulation & AntithromboticsIn 656 patients with anterior large-vessel-occlusion stroke, thrombectomy alone was noninferior for 90-day disability versus alteplase before thrombectomy.