SGEM#322: TXA for SAH – Won’t Stop Me Now

Essais extraits du podcast de Dr. Ken Milne

• 2021ULTRAOtherIn 955 patients with CT-proven subarachnoid haemorrhage, ultra-early tranexamic acid did not improve 6-month functional outcome compared with usual care alone.
• 2017Ottawa SAH RuleImaging & DiagnosticsIn 1153 alert adults with acute headache, the Ottawa SAH Rule detected every subarachnoid haemorrhage compared with the full diagnostic workup.
• 2018TICH-2OtherIn2325 adults with acute spontaneous intracerebral haemorrhage within 8 h of onset,tranexamic aciddid not improvefunctional outcome at 90 dayscompared withplacebo.
• 2011Sensitivity of CT within six hours of headache onset for subarachnoid haemorrhageImaging & DiagnosticsIn3132 emergency patients with acute headache,CT within six hours of onsetdetected allsubarachnoid haemorrhages, unlikescanning later after onset.
• 2015Lumbar Puncture After Normal Head CT in Suspected Subarachnoid HaemorrhageImaging & DiagnosticsIn 2,248 adults with acute non-traumatic headache and a normal head CT, lumbar puncture with CSF spectrophotometry revealed an aneurysm or other vascular abnormality in only 0.4%
• 2002Immediate tranexamic acid and early rebleeding after aneurysmal subarachnoid hemorrhageOtherIn 505 patients with aneurysmal subarachnoid haemorrhage, immediate short-term tranexamic acid reduced early rebleeding compared with no antifibrinolytic treatment.