SGEM Xtra: Dogmalysis 2021

Ensaios extraídos do podcast de Dr. Ken Milne

• 2020Risk of Nonunion with Nonselective NSAIDs, COX-2 Inhibitors, and OpioidsOtherIn339,864 fracture episodes in adults with long-bone fractures,COX-2 inhibitors and opioidswere associated with morenonunion within 1 year, whereasnonselective NSAIDswere not.
• 2021Short-Term Topical Tetracaine for Pain Caused by Corneal AbrasionsEmergency & ResuscitationIn118 adults with uncomplicated corneal abrasion,short-term topical tetracainereducedpain at 24 to 48 hourscompared withplacebo.
• 2014Topical tetracaine used for 24 hours is safe and rated highly effective by patients for the treatment of pain caused by corneal abrasionsEmergency & ResuscitationIn 116 adults with uncomplicated corneal abrasion, topical tetracaine for 24 hours did not impair corneal healing and was rated more effective than saline drops.
• 2016Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution in GastroenteritisEmergency & ResuscitationIn 647 children with mild gastroenteritis, dilute apple juice and preferred fluids reduced treatment failure compared with electrolyte maintenance solution
• 2019CRASH-3Emergency & ResuscitationIn 12 737 adults with acute traumatic brain injury, tranexamic acid did not significantly reduce head injury-related death within 28 days compared with placebo.
• 2020Prehospital TXA for TBI TrialEmergency & ResuscitationIn 966 patients with moderate or severe traumatic brain injury, out-of-hospital tranexamic acid did not improve 6-month neurologic outcome compared with placebo.
• 2010CRASH-2Emergency & ResuscitationIn 20,211 trauma patients with or at risk of significant bleeding, tranexamic acid within 8 h of injury reduced 4-week all-cause mortality compared with placebo.
• 2017WOMANEmergency & ResuscitationIn20 060 women with post-partum haemorrhage,tranexamic acidreduceddeath due to bleedingcompared withplacebo, but notdeath or hysterectomy.
• 2020HALT-ITEmergency & ResuscitationIn 12 009 adults with acute gastrointestinal bleeding, tranexamic acid did not reduce death due to bleeding within 5 days compared with placebo.
• 2018TICH-2Emergency & ResuscitationIn 2325 adults with acute spontaneous intracerebral haemorrhage, tranexamic acid did not improve 90-day functional outcome or mortality compared with placebo.
• 2018PARAMEDIC2Emergency & ResuscitationIn 8014 adults with out-of-hospital cardiac arrest, epinephrine improved 30-day survival but not favourable neurologic outcome compared with placebo.
• 2004OPALSEmergency & ResuscitationIn5638 patients with out-of-hospital cardiac arrest,advanced life supportadded torapid defibrillation alonedid not improvesurvival to hospital discharge.
• 2011PACAEmergency & ResuscitationIn 534 adults with out-of-hospital cardiac arrest, adrenaline improved return of spontaneous circulation but not survival to discharge compared with placebo.