TrialsgrambêtaRCTs are beautiful

SGEM Xtra: EBM Master Class – McGill University Grand Rounds 2020

10 essais

Essais extraits du podcast de Dr. Ken Milne

  • 2017Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic ShockICU & Critical CareIn 94 ICU patients with severe sepsis or septic shock, hydrocortisone, vitamin C and thiamine lowered hospital mortality compared with historical controls.
  • 2019The Effect of Vitamin C on Clinical Outcome in Critically Ill PatientsICU & Critical CareIn 6,455 critically ill and cardiac surgery patients across 44 randomised trials, vitamin C did not reduce mortality compared with placebo or no therapy.
  • 2020VITAMINSICU & Critical CareIn216 patients with septic shock,vitamin C, hydrocortisone and thiaminedid not prolongtime alive and free of vasopressors to day 7compared withhydrocortisone alone.
  • 2020ACTSICU & Critical CareIn205 adults with septic shock,ascorbic acid, corticosteroids and thiaminedid not reduceSOFA score change at 72 hourscompared withplacebo.
  • 2003Parachute use to prevent death and major trauma related to gravitational challengeOtherIn people undergoing gravitational challenge, parachute use was compared with no parachute for death or major trauma; no randomised trials existed.
  • 2018PARACHUTEOtherIn23 aircraft passengers,jumping with a parachutedid not reducedeath or major traumacompared withan empty backpack.
  • 1816Lesassier Hamilton's controlled trial of bloodletting for camp feverOtherIn 366 soldiers hospitalised with camp fever, bloodletting raised mortality about ten-fold compared with treatment without the lancet.
  • 1784Report of the Commissioners Charged by the King with the Examination of Animal MagnetismOtherIn 14 patients undergoing animal magnetism, sham magnetisation with eyes bandaged provoked the same crises and sensations as genuine magnetisation.
  • 1995NINDSAnticoagulation & AntithromboticsIn 624 patients with acute ischemic stroke within 3 hours of onset, intravenous t-PA increased minimal or no disability at three months compared with placebo.
  • 2008ECASS IIIAnticoagulation & AntithromboticsIn821 patients with acute ischaemic stroke 3 to 4.5 hours after onset,intravenous alteplaseimproved90-day disability-free outcomecompared withplacebo.